The body normally hosts a variety of microorganisms, including bacteria and fungi. Some of these are useful to the body.and others may cause infections. Fungi can live on the dead tissues of the hairs, nails. Nail infections usually develop on nails continuously exposed to warm, moist environments. Nail plate is responsible for penetration of drug across it. Number of conventional formulation like gel, cream and also oral antifungals are available. The nail lacquer is a new concept for treating the nail infections.. The main challenge associated with developing nail lacquers treatment for nail disorders is to deliver the active (antifungal) therapeutically effective concentrations to the site of infection, which is often under nail. However possible means to enhance nail penetration must be explored in greater depth before effective local treatments for fungal nail infections are developed. One of the major difficulties in development is lack of proper in vitro methods to measure the extent of drug permeation across the nail plate. Penetration of topical antifungal through the nail plate requires a vehicle that is specifically formulated for transungual delivery. Emphasize is done on development of a promising antifungal treatment in form of nail lacquer owing to its beneficial advantages.
Loading....